Badania naukowe

 

SMART SCIENCE TO ENHANCE BEAUTY

We combine unique expertises of our scientists, biologists, dermatologists, plastics surgeons, aesthetic doctors and chemists

 

Discovery of a longevity ingredient: TANNIC ACID

Tannic acid is an outstanding ingredient, a polyphenol issued from nature. Tannic acid is particularly present in the bark of Sequoia to protect it from diseases, parasites and fungi, this explains the Sequoia’s exceptional lifespan: some specimens may well exceed 3,000 years.

The antioxidant activity of tannic acid is mainly attributed to its redox properties, which allow him to act as reducing agent, hydrogen donor and singlet oxygen quencher. In addition, it possesss metal chelation properties [1]
The polyphenolic nature of tannic acid (hydrophobic core and hydrophilic shell) is also responsible for its antioxidant action [2]:
These properties make it a unique ingredient for:

– Iron chelating complexion
– Hydrogen peroxide and free radicals sca- venger
– Powerful antioxidant
– Superoxide anion radical scavenger
– Regulates pigmentation
– Enhances collagen synthesis

For the first time, Alphascience has managed to use highly concentrated Tannic Acid in its formulations to protect, restore and maintain the integrity of skin cells for exceptional protective results.
[1] Rice-Evans, 1995 and Liyana-Pathirana and Shahidi, 2006
[2]Isenburg et al., 2006

 

 

First vectorisation of L-GLUTAMINE

A sufficient supply of glutamine (NH2-CO-CH2-CH2-CH(NH2) COOH) is important for firm and supple skin. If not enough glutamine is available, the body takes the necessary protein from muscle mass and converts it to glutamine and energy. This leads to proteins being lost, muscle stands becoming thinner and the skin becoming generally saggy. This is why glutamine has been referred to as an « internal fountain of youth » by scientists.

Naturally present in the human body, glutamine is involved in collagen synthesis in direct stimulation[3] and as a precursor of proline and hydroxyproline. Although glutamine is known as an important stimulator of collagen biosynthesis in collagen-producing cells.

In cultured cells[4], scientists found that glutamine is a potent collagen biosynthesis stimulator (it induces an increase in collagen biosynthesis of 400% after 12 hours of incubation).

 

 

 

L-GLUTAMINE PROPERTIES

Increase nucleotide synthesis.

Increase protein turn over in muscles by stimulation of proteasomes

Antiglycation effect by stimulation of glycogenesis

Direct effect on cicatrization and inflammation

 

[3] Bellon G. et al., Glutamine increases collagen gene transcription in cultured human fibroblastsActa 1268, 311-323, 1995)

[4] Karna E. et al, The potential mechanism for glutamine-induced collagen biosynthesis in cultured human skin fibroblasts, Comparative Biochemistry and Physiology, Part B 130, 23-32 (2001)

For the first time, GLUTAMINE has been vectored by Alphascience as a dipeptide which acts as a powerful collagen booster to reduce wrinkles and improve skin density.

 

 

Neutralisation of pollutants: α-NO COMPLEX

The neutralization of air pollutants, aggravating factors for skin disorders.

The latest dermatological clinical studies show that air pollution combined with UV is responsible for 60% of premature aging of the skin.

It has also been demonstrated that the pollutants potentiate the harmful effects of sunlight by multiplying by 4 the UV radiation deleterious effects on skin cells and thereby increasing the photo-actinic damages: wrinkles, brown spots, melasma and skin sagging.

 

 

α-NO COMPLEX dual action:

 

1. Neutralizes the action of Reactive Oxygen Species (ROS), whose harmful ac- tion is stimulated by pollutants at the cellular level for a maximum anti-aging protective efficiency.
2. An action chelating of heavy metals (Fe, Pt catalysts), and complexation of the micro particles present in the pollution (NOx, O3, PM2.5).